In the world of weed, people usually think of sativas as the energizing head high strains,  while indicas are the potent, sedating body high strains. While these generalizations of effects may have been applicable once upon a time, the truth is that very few 100% sativa or 100% indica genetics are available to the public — or even exist at all anymore. 

Most of us are just smoking hybrids.

Hybrid cannabis strains are the result of cannabis breeders spending the past few decades crossing pure sativa genetics with pure indica genetics in the hopes of creating the “perfect” cannabis strains that every consumer could enjoy. Because of this, we now have thousands of strains that can make us feel a whole spectrum of ways. With so many hybrid options, choosing the right ones based on effects can be pretty overwhelming. 

To ease the stress of browsing dispensary menus for hours, here are seven of the best hybrid cannabis strains ever.

OG Kush

Since its birth in the 1990s, Original Kush, better known as OG Kush, has been the backbone of California cannabis culture and genetics. As a result, there isn’t a strain out there that hasn’t been crossed with it; and usually, no matter the cross, those Kush attributes tend to be pretty dominant. Despite its fame, none of us really know for a fact which exact genetics created OG Kush. All we know is how it should make us feel. 

OG Kush is known for providing potent effects suited best for those who can tolerate a high THC content. The high is generally a hard-hitting cerebral euphoria that leaves consumers feeling relaxed and goofy (i.e. stoned for hours at a time). While a heavy high, OG Kush isn’t thought to be a sleepy strain, though you can definitely smoke yourself into the couch with large doses.

Skunk #1

In the same breath as OG Kush and its influence on modern hybrids, we also have to mention Sam the Skunkman’s Skunk #1. It’s a classic cross of Afghani, Acapulco Gold, and Colombian Gold and is world-renowned for producing a pungent funk that smells like a skunk. Additionally, since the 70s, it’s been used to create many of the world’s favorite strains, UK Cheese being the most popular.

Past the skunky terpenes, the Skunk #1 high usually leaves people feeling happy, relaxed, and uplifted. If you need a daytime strain that can help push you through a typical Monday, this might be the hybrid for you.


Gas. When we see Chemdog, all we think is gas. 

This legendary strain, whose story began as some bagseed found at a 1970s Grateful Dead concert, is the reason why we all love cannabis flowers that produce a diesely flavor profile. Like most old school strains, no one really knows its genetic history. What we do know is that famous chemmy terpene profile and the extremely potent high that follows.

Chemdog is the definition of couch-locking cannabis. Just a couple hits may leave you too high for activities. Because of its mind-numbing effects that quickly spread throughout the body, it is often best to consume this hybrid towards the end of the day — or night, for that matter.

White Widow

White Widow is so fun to smoke. It’s truly one of my go-tos when I want a strain that’ll make me feel happy and care-free. And the flowers are beautiful with a thick, white coat of trichomes.

White Widow was bred by crossing a Brazilian landrace with a South Indian landrace. It’s the perfect hybrid in terms of a long-lasting experience with effects that won’t bog you down. Anyone looking for a relaxed yet social high can probably stop right here. 

GSC (formerly Girl Scout Cookies)

To know cannabis in 2020 is to know Cookies; it’s genetics are virtually inescapable at this point.

Formerly known as Girl Scout Cookies (but changed to GSC for legal reasons) this strain is the pride and joy of the Bay Area’s famous Cookie Fam. It’s a cross between Durban Poison and OG Kush that produces incredibly high THC percentages and long-lasting cerebral effects that apply to any time of day, much like OG Kush.

Original Glue (formerly GG#4)

Another strain, another name change due to legal reasons. 

Original Glue is the artist formerly known as Gorilla Glue #4. It’s a hybrid with a complex mix of Chem’s Sister, Chocolate Diesel, and Sour Dubb genetics. It tends to have an earthy and somewhat diesel aroma. 

If you came here looking for a hybrid that’ll lock you down for the next few hours, Original Glue was literally named for having effects so potent that consumers are left glued to the couch. 

Wedding Cake

Wedding Cake seems to be the newest people’s champ of hybrid cannabis strains. It’s a phenotype of Seed Junky’s Triangle Mints strain that was named for its supposed vanilla frosting taste. Unfortunately, many of us just think it tastes like earthy dough. 

The effects tend to follow the road paved by OG Kush and GSC, as anytime hybrids that produce a potent, long-lasting euphoria that often hits hardest in the mind. 

Find thousands of strains on Weedmaps

Featured image by Gina Coleman/Weedmaps

I’m a cannabis media expert specializing in writing engaging articles and creating entertaining video content around strains, products, and information. Basically, if you want to teach people about cannabis: what to buy, what/how to consume, why, and general FAQs on any level, I’m your guy.

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